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PI3K Signaling Pathway Analysis: A Shifting Marketed and Pipeline Product Landscape, as Blockbusters Expire and Development Moves Towards Downstream Targets

  • Published: Jul-2018
  • Report Code: GBI090CBR
  • Report Format: pdf

Description

Table of Contents

1 Table of Contents 4

1.1 List of Tables 4

1.2 List of Figures 5

2 Introduction 7

2.1 Role of PI3K in Disease 10

2.1.1 Oncology 10

2.1.2 Central Nervous System 12

2.1.3 Ulcerative Colitis 13

3 Marketed Products Landscape 15

3.1 Overview 15

3.2 Key Signaling Pathways within the PI3K Marketed Product Landscape 15

3.2.1 PI3K/AKT/mTOR Pathway 15

3.2.2 Ras/Raf/MEK/ERK Pathway 19

3.2.3 Cell Survival Pathways Downstream of AKT 20

3.2.4 Cell Cycle Progression Pathways Downstream of AKT 23

3.2.5 Kinases Downstream of PDK1 25

3.3 Key Marketed Products 26

4 Pipeline Products Landscape 45

4.1 Overview 45

4.2 Key Signaling Pathways within the PI3K Pipeline Product Landscape 45

4.2.1 PI3K/AKT/mTOR Pathway 45

4.2.2 Ras/Raf/MEK/ERK Pathway 50

4.2.3 Cell Survival Pathways Downstream of AKT 53

4.2.4 Cell Cycle Progression Pathways Downstream of AKT 58

4.2.5 Metabolism Pathways Downstream of AKT 62

4.2.6 Kinases Downstream of PDK1 66

4.2.7 Clinical-Stage Pipeline Products 69

4.2.8 List of All Pipeline Products 82

5 Appendix 256

5.1 References 256

5.2 Abbreviations 259

5.3 List of PI3K Pathway Nodes 262

5.4 About GBI Research 266

5.5 Disclaimer 266

 
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